125-10-0 Pharmaceutical intermediate purity 99% prednisone acetate 125-10-0

Prednisone 21-acetate
Product Name
Prednisone 21-acetate
Melting point
Boiling point
582.0±50.0 °C
Storage temp.
1.28±0.1 g/cm3

 Main ingredients: The main ingredient of this product is prednisone acetate. Indications:This product is mainly used for allergic and autoimmune inflammatory diseases. It is suitable for connective tissue diseases, systemic lupus erythematosus, severe polymyositis, severe bronchial asthma, dermatomyositis, vasculitis and other allergic diseases, acute leukemia, malignant lymphoma. As well as the conditions applicable to other adrenocortical drugs. Adverse reactions:Larger doses of this product are likely to cause diabetes, gastrointestinal ulcers and Cushing-like syndrome symptoms, and have a strong inhibitory effect on the hypothalamic-pituitary-adrenal axis. Concurrent infection is the main adverse reaction. Taboo:1. Patients with hypertension, thrombosis, gastric and duodenal ulcers, psychosis, electrolyte metabolism abnormalities, myocardial infarction, visceral surgery, glaucoma, etc. should not be generally used. Patients should weigh the pros and cons under special circumstances and pay attention to the possibility of deterioration. 2. Disable patients with a history of allergy to this product and adrenocortical drugs, and patients with fungal and viral infections. Note :

1. When applied to patients with tuberculosis, acute bacterial or viral infections, appropriate anti-infective treatment must be given. 2. After taking the medicine for a long time, it should be gradually reduced when the medicine is stopped. 3. Patients with diabetes, osteoporosis, liver cirrhosis, renal dysfunction, and hypothyroidism should be used with caution. 4. For those infected with bacteria, fungi and viruses, they should be used with caution while applying sufficient amounts of sensitive antibiotics. Medication:Medications for pregnant and lactating women: The use of pregnant women can increase the incidence of placental insufficiency, neonatal weight loss or stillbirth. Animal experiments have teratogenic effects, and the pros and cons should be weighed. Nursing mothers who receive large doses should not breastfeed to prevent the excretion of drugs through milk, which can cause adverse effects such as infant growth inhibition and adrenal function inhibition. Children’s medication:Children who use adrenocortical hormones for a long time must be very cautious, because hormones can inhibit the growth and development of children. If long-term use is necessary, short-acting (such as cortisone) or intermediate-acting agents (such as prednisone) should be used. , Avoid using long-acting preparations (such as dexamethasone). Oral medium-effect preparations every other day can reduce the inhibitory effect on growth. Long-term use of glucocorticoids in children or adolescents must be closely observed. The risk of osteoporosis, ischemic necrosis of the femoral head, glaucoma, and cataracts in children is increased. In addition to the general age and weight, the dosage of hormones for children should also be based on the severity of the disease and the child’s response to treatment. For the treatment of children with adrenal insufficiency, the amount of hormones should be based on the body surface area, if it is determined by body weight, it is prone to Medication for the elderly: Glucocorticoids are prone to high blood pressure, and elderly patients, especially women after menopause, are prone to osteoporosis. medicine interactions:1. Non-steroidal anti-inflammatory analgesics can enhance its ulcer-causing effect. 2. It can enhance the hepatotoxicity of acetaminophen. 3. Combined with amphotericin B or carbonic anhydrase inhibitor, it can aggravate hypokalemia, long-term use with carbonic anhydrase inhibitor, prone to hypocalcemia and osteoporosis. 4. Combined with protein assimilation hormone, it can increase the incidence of edema and make acne worse. 5. Long-term use with anticholinergic drugs (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by them. 7. When used in combination with hypoglycemic drugs such as insulin, the dosage of hypoglycemic drugs should be appropriately adjusted because it can increase the blood sugar of diabetic patients. 8. Thyroid hormone can increase its metabolic clearance rate, so the combination of thyroid hormone or antithyroid drugs should adjust the dosage of the latter appropriately. 9. Combined with contraceptives or estrogen preparations, it can strengthen its therapeutic effect and adverse reactions. 10. Combined with cardiac glycoside, can increase the occurrence of digitalis toxicity and heart rhythm disorders. 11. Combined with potassium excretion diuretics, can cause severe hypokalemia, and weaken the sodium excretion and diuretic effect of diuretics due to water and sodium retention. 12. Combined with ephedrine, it can enhance its metabolic clearance. 13. Combined with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14. Can increase the metabolism and excretion of isoniazid in the liver, reduce the blood concentration and therapeutic effect of isoniazid. 15. It can promote the metabolism of mexiletine in the body and reduce the blood concentration. 16. Combined with salicylate can reduce plasma salicylate concentration. 17. Combined with growth hormone, it can inhibit the latter’s growth promoting effect. Drug Toxicology:Adrenal cortex hormone drugs have anti-inflammatory, anti-allergic, anti-rheumatic, immunosuppressive effects. The mechanism of action is: 1. Anti-inflammatory effect: This product can reduce and prevent the tissue’s response to inflammation, thereby reducing the performance of inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators. 2. Immunosuppression: including preventing or inhibiting cell-mediated immune reactions, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, and reducing the ability of immunoglobulins to bind to cell surface receptors And inhibit the synthesis and release of interleukins, thereby reducing the transformation of T lymphocytes to lymphoblasts and reducing the expansion of the primary immune response. Can reduce the immune complex through the basement membrane, and can reduce the concentration of complement components and immunoglobulins. Pharmacokinetics: This product must show the pharmacological activity after reducing the 11-keto group to the 11-hydroxyl group in the liver, and the physiological half-life is 60 minutes. The distribution in the body is highest in the liver, followed by plasma, cerebrospinal fluid, pleural effusion, ascites, and kidney. In the blood, most of this product is bound to plasma proteins, and free and bound metabolites are excreted from urine, and some are excreted in the original form. A small portion can be discharged through breast milk. Storage: sealed from light

1. Oral administration is usually 5-10mg (1-2 tablets) at a time, 10-60mg (2-12 tablets) a day. 2. For autoimmune diseases such as systemic lupus erythematosus, gastritis syndrome, ulcerative colitis, autoimmune hemolytic anemia, etc., it can be given 40 to 60 mg daily, and gradually decrease after the condition stabilizes. 3. For allergic diseases such as drug-induced dermatitis, urticaria, and bronchial asthma, prednisone can be given 20 to 40 mg per day. After the symptoms are alleviated, the amount should be reduced by 5 mg every 1-2 days. 4. To prevent rejection of organ transplantation, it is generally started to take 100 mg orally every day 1 to 2 days before the operation, and it will be changed to 60 mg a day one week after the operation. 5. Treat acute leukemia and malignant tumors by taking 60-80 mg orally daily, and reduce the amount after the symptoms are relieved.